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KMID : 1130620080040020094
Journal of Clinical Neurology
2008 Volume.4 No. 2 p.94 ~ p.98
Severe Episodic Memory Impairment in a Patient With Clinical Features Compatible With Corticobasal Degeneration
Kim Sung-Kwan

Kang Do-Young
Kim Jae-Woo
Kim Sang-Ho
Cha Jae-Kwan
Park Kyung-Won
Abstract
Corticobasal degeneration (CBD) is a progressive neurodegenerative disorder characterized by asymmetric
parkinsonism associated with apraxia, cortical sensory loss, and alien-limb phenomenon. Neuropsychological testing
in patients with CBD typically shows deficits in executive functions, praxis, language, and visuospatial functioning,
but not in memory. We report a CBD patient with severely impaired memory function but relatively mild motor
symptoms. Detailed neuropsychological assessment showed significant verbal and visual memory deficits accompanied
by frontal executive dysfunctions. Our observations indicate that CBD can in rare cases present with severe episodic
memory impairment associated with frontal executive dysfunctions in the early stage of illness.
KEYWORD
Corticobasal degeneration, Episodic memory, PET
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